Assoc.Prof. Hasan Ayaz Drexel University, Cognitive Neuroengineering and Quantitative
Experimental Research Collaborative
Biomedical Engineering, Science and Health Systems "Next-generation wearable and ultra-portable neuroimaging:
expanding vistas for brain health"
Hasan Ayaz is an Associate Professor at Drexel University, School of Biomedical Engineering, Science & Health Systems and College Arts and Sciences, Department of Psychology, with adjunct affiliations the University of Pennsylvania and Children’s Hospital of Philadelphia; and a core member of the Cognitive Neuroengineering and Quantitative Experimental Research Collaborative. He received his BSc. in Electrical and Electronics Engineering at Boğaziçi University and received PhD in Biomedical Engineering in 2010 from Drexel University. For more than 17 years, he worked on the development of miniaturized continuous wave near infrared spectroscopy systems focusing on neuroimaging. He has developed tools for monitoring brain that are now utilized routinely for clinical and field research in university, governmental and corporate labs. He also led the software development of the first optical-brain-monitoring medical device, Infrascanner, which is a portable-handheld instrument that utilizes near infrared to detect hematoma in head trauma patients, tested with 12 independent clinical studies with over 1,200 patients and currently deployed in 42 countries/6 continents in both civilian and military hospitals, already became the standard of care for children and sports medicine in some European countries. Dr. Ayaz’s research involves understanding the neural mechanisms related to human cognitive, and motor functioning with a focus on real-world contexts, mobile neuroimaging, and neuroengineering approaches for neuroergonomics applications. His research aims to design, develop, and utilize (i.e. to measure->elucidate->enable) next generation brain imaging for neuroergonomic applications over a broad-spectrum from aerospace to healthcare. His research has been funded by federal agencies, corporate partners and foundations, and output over 200 publications in international journals and conferences.
Next-generation wearable and ultra-portable neuroimaging: expanding vistas for brain health
Hasan Ayaz1,2,3,4 1 School of Biomedical Engineering, Science & Health Systems, Drexel University, 2Cognitive Neuroengineering and Quantitative Experimental Research (CONQUER) Collaborative, Drexel University, 3 Department of Family and Community Health, University of Pennsylvania, 4 Center for Injury Research and Prevention, Children’s Hospital of Philadelphia,
Philadelphia, PA, 19104, USA
Neuroergonomics is an emerging field that investigates the human brain in relation to behavioral performance in natural environments and everyday settings. Functional near infrared spectroscopy (fNIRS), a noninvasive brain monitoring technology that relies on optical techniques to detect changes of cortical hemodynamic responses to human perceptual, cognitive, and motor functioning, is an ideal candidate tool. Ultra-portable wearable and wireless fNIRS sensors are already breaking the limitations of traditional neuroimaging approaches that imposed limitations on experimental protocols, data collection settings and task conditions at the expense of ecological validity. Moreover, novel utilization of the near infrared light allows the rise of a new generation medical devices, such as the de novo FDA approved Infrascanner, a handheld brain hematoma detection system that is based on the differential near infrared light absorption of the injured vs. the non-injured part of brain. This presentation will summarize our recent progress and emerging trends of fNIRS applications, from aerospace to medicine, with diverse populations and towards clinical solutions including mental health and neurological conditions such as Schizophrenia, and Traumatic Brain Injury.
Prof. Omer Halil Colak Akdeniz University, Electrical and Electronics Engineering "Brain Plasticity and Rehabilitation Oriented Solutions
in Facial Transplant Patients"
Prof. Dr. Ömer Halil Çolak completed his undergraduate and graduate studies at Süleyman Demirel University in Electronics and Communication Engineering. In 2006, he received the title of Doctor of Science in Electronics Engineering from Sakarya University. In 2007, he started to work as an Assistant Professor at Akdeniz University, Faculty of Engineering, Electrical and Electronics Engineering Department.
In 2008, he made researches on autonomic nervous system and sympathovagal balance at University of Technology Zurich and received the 2009 Akdeniz University Science Encouragement Award for his work. In 2010, he continued his postdoctoral research on motor control and synaptic balance at the Paris Descartes University, Faculty of Medicine, Neurosciences Institute. In the same year he was awarded, Elsevier-France The Young Scientist of the Year Award. Dr. Çolak, received a title Associate Professor in 2013 and Professor in 2018 and he is currently continuing his academic life at Akdeniz University.
Dr. Çolak founded the Neural Science Laboratory in the Electrical and Electronics Engineering Department of Akdeniz University in 2013. In the same year, with the contributions of Electronic Engineering, Neurology, Plastic and Reconstructive Surgery, and Radiology, he initiated studies on the solutions of brain plasticity and muscle movements in face and arm transplant patients. He is currently working as a group leader in neuroscience laboratory for face transplantation, arm transplantation, arm replant, complete facial lesions, amputation groups and athletes, analyzing brain and muscle dynamics and improving rehabilitation processes.
Assoc.Prof. Sinan GUVEN Dokuz Eylul University
Izmir International Biomedicine and Genome Institute
"Tissue Engineering and Microfluidic Systems"
Sinan Güven received his BSc degree in Chemistry from Middle East Technical University and master's degree in Biotechnology from the same university. In 2011, he completed his doctorate in tissue engineering and stem cells at the Switzerland, University of Basel. His doctoral studies were based on the preparation of large-scale vascularized bone grafts using adult stem cells. He also worked on differentiation of stem cells and transfer of regenerative medicine applications in clinical areas. He conducted his post-doctoral studies in the USA between 2012-2015. During his studies at the Massatchussetts Institute of Technology (MIT), Harvard Medical School and Brigham and Women’s Hospital, he focused on 3-dimensional bottom-up tissue engineering joining technologies and microfluidic systems. However, it has developed models that mimic real tissue and organ functions for regenerative and personal medical applications. Dr. Güven has designed innovative micro-environments for cancer research using bioengineering tools at the Stanford Canary Early Cancer Diagnosis Center. In May 2015, he returned home. He joined Dokuz Eylul University Faculty of Medicine and Izmir Biomedicine and Genome Center and established Therapeutic Bioengineering Medicine Center. At present, he is working as a group leader in tissue engineering, stem cells and microfluidic systems. Assoc. Dr. Sinan Güven was awarded the 2016 Turkey Academy of Sciences TUBA-GEBIP, 2017 Academy of Sciences BAGEP and 2018 Turkey Institutes of Health Presidency TÜSEB Promotion Award.
"Tissue Engineering and Microfluidic Systems"
Tissue engineering aims at the purpose of today's medical treatment tools to be designed and re-designed to artificially control new tissues and organs or tissue models. It aims to accelerate and regeneration by contributing to the body's healing by implanting the designed tissues into the damaged organ or region. The tissue engineering method also allows for the development of model tissue/organ for clinical research and the pharmaceutical industry. The most important benefits of this method are: 1) using the patient's own cells to regulate the most healthy and correct drug or drug dose without damaging the patient, 2) minimizing the ethical concerns by reducing animal experiments, 3) creating platforms suitable for the development of new drugs and treatment methods, and finally 4) to provide healing of damaged tissues and organs by developing alternative and innovative techniques in addition to existing surgical methods. In this area, stem cells are used as regenerating medicine and tissue engineering applications because of their role in tissue repair. Artificial tissues developed using stem cells and their long life are dependent on their maturation stages in vitro and in vivo. The 3-dimensional top-up regenerative medicine applications have brought new dimensions to bioengineering. Besides, the direct application of innovative methods and developments in engineering to health sciences has provided new platforms such as chip-organ in biomedicine field. In this presentation, we will discuss the use of stem cells in tissue engineering and the use of artificial tissues in microfluidic chip systems. On the other hand, especially in recent years, single cell genomic analyzes with microfluidic systems and their possibilities in cancer research will be discussed.